Anatomical MRI findings in autism are likely to be of low clinical and scientific significance Conference Paper uri icon


  • Previous studies with small samples have reported that individuals with autism spectrum disorders (ASD) exhibit numerous anatomical brain abnormalities when compared with controls. The recent release of the Autism Brain Imaging Data Exchange (ABIDE,> 1000 participants, ages 6-65) offers an important opportunity to perform more definitive large- scale comparisons between ASD and control individuals who span a wide range of IQ scores, ages, and symptom severities. Anatomical Magnetic Resonance Imaging (MRI) scans of 348 male ASD participants and an equal number of age, gender, and IQ matched controls were selected for the current study. We performed comprehensive univariate and multivariate analyses using multiple volumetric, cortical thickness, and cortical surface area measures derived for each of 150+ brain areas. Significant findings were almost entirely …

publication date

  • August 1, 2014