Immune Surveillance and Feto-Maternal Relationships: Suppression of Immune Functions by Mouse Amniotic Fluid Academic Article uri icon


  • Summary A study was made of the effects of mouse amniotic fluid (MAP) on various immune reactions. We found that MAF inhibits primary antibody responses tosheep red blood cells (SRBC). In an attempt to characterize the target cell for its suppressive effect, we studied an experimental system in which antigen—fed macrophages signal T cells in culture. We found that MAF suppresses the specific immunogenic signal of macrophages to T cells in this system. Mixed lymphocyte reactions (MLR) against alloantigens either by the total spleen …

publication date

  • January 1, 1979