- Objective: Estimating the prevalence of Mild Cognitive Impairment (MCI), Alzheimer9s disease (AD) and the rate of conversion from MCI to AD in an elderly Arab population. Background While older age influences the conversion from MCI to AD, the effect of gender and education is equivocal. Studies in populations with low schooling are reportedly rare. Design/Methods: We performed a door-to-door study of all residents aged > 65 years in Wadi-Ara, an Arab community in northern Israel. Medical, family history and medications were recorded. Subjects were classified as cognitively normal (CN), MCI, AD or other based on neurological and cognitive examination in Arabic. MCI patients were re-examined at least one year later to determine the conversion to AD and the contributions of age, gender and education to the probability of conversion. Results: Of the 944 participants (96.6% of those approached; 49.4% men), 303 (32.1%) had MCI and 92 (9.8%) AD. Seventy seven percent of women had no schooling, therefore we estimated the effect of gender on the risk of AD and MCI among subjects without schooling (n=452) and the effect of education among men (n=318). Stepwise logistic regression analysis among subjects without schooling revealed that older age (p=0.02, OR=1.2, 95%CI 1.14-1.27) and female gender (p Conclusions: Female gender and lack of formal education are risk factors for AD and MCI, but do not increase the probability of conversion from MCI to AD in this population. Supported by: NIH RO1 AG017173. Disclosure: Dr. Afgin has nothing to disclose. Dr. Massarwa has nothing to disclose. Dr. Schechtman has nothing to disclose. Dr. Israeli-Korn has nothing to disclose. Dr. Strugatsky has nothing to disclose. Dr. Abuful has nothing to disclose. Dr. Farrer has nothing to disclose. Dr. Friedland has nothing to disclose. Dr. Inzelberg has nothing to disclose.