P1084: Motor effects of deep repetitive transcranial magnetic stimulation with H-coil in Parkinson’s disease: a randomized, double blind, placebo-controlled study Academic Article uri icon

abstract

  • Methods: We studied metaplasticity by testing the interactions of priming TBS with LTP/D-like plasticity induced by subsequent test TBS. Changes in excitatory neurotransmission were measured by the input-output curve of motor evoked potentials (IO-MEP), and changes in GABAAergic inhibitory neurotransmission by the input-output curve of short-interval intracortical inhibition (IO-SICI, 4 conditioning stimulus intensities of 70-100% active motor threshold, interstimulus interval 2.0 ms). Results: Non-primed iTBS increased IO-MEP, while non-primed cTBS decreased IO-MEP. Pairing of identical protocols (iTBS→ iTBS, cTBS→ cTBS) resulted in suppression of the non-primed TBS effects on IO-MEP, and pairing of different protocols (cTBS→ iTBS, iTBS→ cTBS) enhanced the test TBS effects on IO-MEP. While non-primed TBS did not result in significant changes of IO-SICI, iTBS→ iTBS …

publication date

  • January 1, 2014