Modulation of measles virus expression and protein kinase C in neuroblastoma cells by anti-measles antibodies Academic Article uri icon

abstract

  • B. Rager-Zisman. Microbiology and Immunology, Ben Ourion University, Beer Sbeva," Israel and Virologie und Immunbiologie, Universitat Wurzburg, G e~ y Measles virus (MV), a negative strand RNA virus of the paramyxovims family is among the infectious agents displaying a propensity for establishing persistent infections of the CNS. This virus has been isolated from patients with SSPE and may be involved in the pathogenesis of other neurological disorders. Measles virus is capable of infecting various kinds of cells in culture, causing an acute lyric effect. We have established a persistent infection of a murine neuroblastoma cell line (NS20Y/MS) and demonstrated that the viral L~ ection resulted in increased levels of protein kinase C activity. To investigate whether this effect is directly correlated with measles virus gene expression and the accumulation of measles v~ ms …

publication date

  • January 1, 1991