653: Fragment Bb: evidence for activation of the alternative pathway of the complement system in pregnant women with pyelonephritis Academic Article uri icon

abstract

  • Objective Pyelonephritis has a more severe course during pregnancy than in the non- pregnant state. This has been attributed to an increased susceptibility of pregnant women to microbial products. The complement system is part of innate immunity and its alternative pathway is activated mainly by microorganisms. The purpose of this study was to determine if activation of the alternative pathway of the complement system (fragment Bb) occurs in pregnant women with acute pyelonephritis. Study Design A cross sectional study was conducted to determine the maternal plasma concentrations of fragment Bb in patients complicated with acute pyelonephritis (n= 38) and in those with a normal pregnancy (n= 62). Fragment Bb was measured using ELISA. Non-parametric statistics were used for analysis. Results 1) Pregnant women with pyelonephritis had a significantly higher median plasma …

publication date

  • December 1, 2009