Efficacy of 13-Valent Versus 7-Valent Pneumococcal Conjugate Vaccine Against Nasopharyngeal Colonization of Antibiotic-Nonsusceptible Streptococcus pneumo... Academic Article uri icon


  • ABSTRACT Background: Pediatric respiratory infections caused by antibiotic- nonsusceptible Streptococcus pneumoniae (ANSP) continue to present an important challenge, even after PCV7 implementation. This randomized double-blind trial assessed the potential additional impact of PCV13 over PCV7 on reduction of ANSP carriage. Methods: Healthy infants were randomly assigned to receive PCV13 (n= 932) or PCV7 (n= 934) at ages 2, 4, 6, or 12 months. Eight nasopharyngeal swabs were collected between …

publication date

  • January 1, 2014