650: Smoking during pregnancy as a possible risk factor for pediatric neoplasms in the offspring: A population-based cohort study Academic Article uri icon


  • Objective The link between fetal origins and the development of adult diseases is now well established. The potential long-term effect of intrauterine exposures on offspring's health is of major interest. We aimed to evaluate the effect of maternal smoking during pregnancy on the long-term risk for pediatric neoplasms in the offspring. Study Design A population based cohort analysis was performed comparing the risk for long-term pediatric neoplasms (up to the age of 18 years) in children born to mothers who smoked during pregnancy and those who did not. Pediatric neoplasms were pre-defined based on ICD-9 codes, as recorded in the hospital computerized medical files. Deliveries occurred between the years 1991-2014 in a regional tertiary medical center. Kaplan-Meier survival curves were used to compare cumulative oncological morbidity in both groups over time and Cox proportional hazards …

publication date

  • January 1, 2018