Transcranial magnetic stimulation of deep brain regions in Alzheimer's disease Academic Article uri icon


  • Background: rTMS is a non-invasive technique using magnetic coils to painlessly stimulate brain regions to influence cortical activity. Deep-rTMS allows for stimulation of deeper brain structures, thereby potentially providing more significant effects on brain activity and function. rTMS studies suggest that stimulation can produce long term changes in cortical synapses akin to LTP and LTD, and might influence neuronal regulation and network patterns. In a placebo-controlled, double-blind, pilot study we evaluated the safety and feasibility of high frequency and low frequency deep-rTMS to prefrontal areas of AD patients receiving stable doses of accepted AD medications.

publication date

  • July 1, 2014