What Do Antibiotics Really Do In AOM? Academic Article uri icon


  • It is well recognized that appropriately chosen antibiotics enhance bacteriologic eradication in culture-positive AOM. It is also established that if bacteriologic eradication does not occur within 3—5 days of treatment, the risk of clinical failure at the end of the treatment increases∼ 5 fold. However, even with the 5-fold increase, over 50% of those from whom organisms were not eradicated after 3—5 days are still doing well at the end of treatment. New evidence demonstrates that among those who, despite failure of eradication after 3—5 days of treatment, have clinical improvement or cure at the end of treatment, recurrence of AOM occurs 35% more frequently than among those with eradication. Furthermore, in these cases only 34% will have new organisms, vs. 64% among those from whom bacteria were eradicated. New evidence also shows that nasopharyngeal (NP) carriage at initiation and …

publication date

  • January 1, 2008