Mitochondria control store-operated Ca 2+ entry through Na+ and redox signals Academic Article uri icon


  • Abstract Mitochondria exert important control over plasma membrane (PM) Orai1 channels mediating store‐operated Ca 2+ entry (SOCE). Although the sensing of endoplasmic reticulum (ER) Ca 2+ stores by STIM proteins and coupling to Orai1 channels is well understood, how mitochondria communicate with Orai1 channels to regulate SOCE activation remains elusive. Here, we reveal that SOCE is accompanied by a rise in cytosolic Na+ that is critical in activating the mitochondrial Na+/Ca 2+ exchanger (NCLX) causing …

publication date

  • February 20, 2017