Review: The Vicious Circle of Stress and Anticholinesterase Responses Academic Article uri icon


  • After either acute psychological stress or exposure to acetylcholinesterase (AChE) inhibitors, long-lasting deleterious changes of a similar nature occur in the mammalian brain. We explored the molecular and neurophysiological mechanisms preceding these convergent delayed consequences in vivo and in perfused hippocampal brain slices. In stressed mice, we observed a disruption of the blood-brain barrier, which leads to efficient brain penetrance of anti-AChEs. This increase in penetrance of anti-AChEs, and consequently in …

publication date

  • May 1, 1999