Insight into Disease Processes through Studies of the Intracellular Vesicle Transport System Academic Article uri icon

abstract

  • Eukaryotic cells synthesize different types of molecules that are transported within the cell to discrete areas, or secreted outside of the cell, in small packages, called vesicles. The mechanism by which intracellular vesicles carrying distinct cargo molecules are delivered to specific cellular compartments, and the means by which vesicles fuse with specific organelles or the plasma membrane, to deliver their cargo, is the focus of intense investigation by many laboratories. Studies performed by three pioneering scientists, who won the 2013 Nobel Prize in Physiology or Medicine, contributed significantly to the understanding of these mechanisms. The three Laureates, James E. Rothman, from the Department of Cell Biology, at Yale University in New Haven, Connecticut, Randy W. Schekman, from the Department of Molecular and Cell biology, at the University of …

publication date

  • January 1, 2014