Expression of PKCêta in NIH-3T3 cells promotes production of the pro-inflammatory cytokine interleukin-6. Academic Article uri icon


  • INTRODUCTION Protein kinase C (PKC) is involved in several major signal transduction pathways that control gene expression, cell growth and differentiation. Its activation, upon stimulation of cells by various external ligands, including hormones, neurotransmitters and growth factors, is generally believed to occur in response to a rise in intracellular levels of diacylglycerol (DAG) [1, 2]. This transient rise of DAG is [...]

publication date

  • January 1, 1999