Rapid reduction in invasive pneumococcal disease after introduction of PCV7 into the National Immunization Plan in Israel. Academic Article uri icon


  • Background The 7-valent conjugated vaccine (PCV7) was introduced into the Israeli National Immunization Program (NIP) in July 2009 (2, 4, 12 months schedule; 2 dose catch- up in second year of life). Nationwide active prospective surveillance on invasive pneumococcal disease (IPD) has been conducted in children since 1989. In the current study, IPD epidemiology in children< 5 years during the 20 years before and 18 months after PCV7 NIP initiation, is reported. Methods All 27 centers performing blood/cerebrospinal fluid (CSF) cultures in children reported monthly IPD cases. Capture–recapture approach was used for completeness. Results During 1989–2010, 6022 IPD cases were reported in children< 5 years; PCV7 serotypes (7VST) caused∼ 50% of all episodes. In 2009 and 2010, 7VST IPD incidences< 5 years of age (per 100,000) were 15.9 and 5.4, respectively (a 43 …

publication date

  • January 1, 2012