Role of raf and myc oncogenes in signal transduction Academic Article uri icon

abstract

  • Oncogenes are derived from normal cellular genes which encode elements of signal transduction pathways that regulate cell growth. At least some of these genes are also active in postmitotic tissues where they presumably orchestrate signaling traffic of inter-and intracellular communications affecting expression and/or activity of differentiated cellular functions. The emerging picture of mitogen signal transduction consists of a cascade of cytoplasmic protein kinases which translate the signal from an activated transmembrane …

publication date

  • January 1, 1989