Assessment of Blood-Brain Barrier Breakdown Academic Article uri icon


  • Abstract The blood–brain barrier (BBB) is a structural and functional barrier which limits the free passage of ions and large molecules between the blood and brain. BBB functions are often impaired in neurological disorders, more often in vascular-related injuries, stroke, intracerebral, and subarachnoid hemorrhage. Recently, it has been demonstrated that injury to the BBB and the diffusion of serum proteins into the brain's extravascular space are directly related to immediate astrocytic transformation followed by neuronal dysfunction …

publication date

  • January 1, 2012