OC114: Abnormal Doppler velocimetry and SGA: Evidence for the relationship between utero-placental insufficiency and a maternal anti-angiogenic state Academic Article uri icon


  • Objectives Utero-placental ischemia has been implicated as one of the mechanisms of disease in SGA. Recently, an anti-angiogenic state (reflected by elevation of soluble endoglin concentrations in maternal blood) has been described in mothers with SGA fetuses without preeclampsia and detected as early as the first trimester of pregnancy. The objective of this study was to determine if mothers of SGA fetuses with and without Doppler abnormalities have different profiles of the anti-angiogenic factor, soluble endoglin (sEng). Study design A cross-sectional study was conducted in 46 pregnancies which led to the birth of SGA neonates. SGA were sub-classified according to the results of uterine (UT) and umbilical (UA) artery Doppler velocimetry. The control group consisted of normal pregnant women who delivered appropriate for gestational age neonates (n= 135). Plasma …

publication date

  • January 1, 2008