Pretreatment With Premarin Does Not Affect Neurological Outcome After Closed Head Injury in Rats Academic Article uri icon


  • Methods: With institutional approval, male rats were anesthetized with halothane, an intravenous catheter was placed, blood was sampled for measurement of blood glutamate concentration (baseline), and premarin (1 mg/kg) or an equal volume of saline was given. After 1 h, blood again was taken for glutamate measurement and either CHT (0.5 J) was delievered or no CHT was delivered. Halothane was discontinued, and rats were assigned to one of 4 groups: group 1= saline/no CHT, group 2= premarin/no CHT, group 3= saline/CHT, and group 4= premarin/CHT. Assignment continued until there were 6 surviving rats in each group. At 1 h after CHT vs no CHT (2 h after giving premarin or saline), neurological severity score (NSS; a 25-point scoring system of behavior and motor functions in which 0= intact neurological condition and 25= severe neurological dysfunction) was …

publication date

  • January 1, 2005