Emergence of Streptococcus pneumoniae Serotype 12F after Sequential Introduction of 7- and 13-Valent Vaccines, Israel Academic Article uri icon


  • Israel implemented use of 7-and 13-valent pneumococcal vaccine in 2009 and 2010, respectively. We describe results of prospective, population-based, nationwide active surveillance of Streptococcus pneumoniae serotype 12F (Sp12F) invasive pneumococcal disease (IPD) dynamics in the 7 years after vaccine introduction. Of 4,573 IPD episodes during July 2009–June 2016, a total of 434 (9.5%) were caused by Sp12F. Sp12F IPD rates (cases/100,000 population) increased in children< 5 years of age, from 1.44 in 2009–2010 to> 3.9 since 2011–2012, followed by an increase in all ages. During 2011–2016, Sp12F was the most prevalent IPD serotype. Sp12F isolates were mostly penicillin nonsusceptible (MIC> 0.06 µg/mL; MIC 50= 0.12) and predominantly of sequence type 3774), a clone exclusively found in Israel (constituting≈ 90% of isolates in 2000–2009). The sharp …

publication date

  • January 1, 2018