Intramyocellular triacylglycerol accumulation across weight loss strategies; Sub-study of the CENTRAL trial Academic Article uri icon

abstract

  • Background Intramyocellular triacylglycerol (IMTG) is utilized as metabolic fuel during exercise and is linked to insulin resistance, but the long-term effect of weight loss strategies on IMTG among participants with abdominal fat, remain unclear. Methods In an 18-month trial, sedentary participants with abdominal fat/dyslipidemia were randomized to either a low- fat (LF) or Mediterranean/low-carbohydrate (MED/LC) diet (including 28g· day-1 of walnuts). After 6-months, the participants were re-randomized to moderate intense physical activity (PA+) or non-physical activity (PA-). Magnetic resonance imaging (MRI) was used to quantify changes of IMTG, abdominal sub-depots, hepatic and intermuscular fats. Results Across the 277 participants [86% men, age= 48 years, body-mass-index (BMI)= 31kg/m2, visceral fat= 33%] 86% completed the 18-m trial. At baseline, women had higher IMTG than men (3.4 …

publication date

  • January 1, 2017