Right prefrontal deep TMS effects on attention: Electrophysiological correlates Academic Article uri icon

abstract

  • Despite its increasing use in clinical practice our knowledge on the cellular and molecular mechanisms underlying repetitive transcranial magnetic stimulation (rTMS)-based therapies remains limited. Hence, a deeper understanding of rTMS-induced neural plasticity is required to optimize current treatment protocols and/or to develop new diagnostic and therapeutic strategies using rTMS. Studies in small animals or appropriate in vitro preparations (including models of brain diseases) provide highly useful experimental approaches in this context. Recently, we succeeded in establishing an in vitro model of repetitive magnetic stimulation (rMS) using organotypic hippocampal slice cultures. This approach provides a set of noteworthy advantages, such as (i) excellent preservation of in vivo connectivity,(ii) a laminar fiber-and cytoarchitecture, and (iii) the possibility to …

publication date

  • January 1, 2015