- Fetal gallstones detected by routine third trimester ultrasound are a rare finding with controversial clinical significance. Kiserud et al.  established a list of predisposing factors associated with fetal echogenic gallbladder, including congenital malformations such as tetralogy of Fallot, bilateral clubfoot, and gastroschisis, chromosomal abnormalities (trisomy 21, translocation 10; 11) and extra-amniotic hematoma with intrauterine growth restriction. Other studies, on the contrary, found fetal gallstones as a benign, isolated condition [2,3]. The present study was aimed to further investigate the clinical significance of fetal gallstones during the third trimester.