Synthesis of 1,3,4-thiazole derivatives by the reaction of thiobenzhydrazide with some acylacetylenes Academic Article uri icon

abstract

  • 2-Acylmethyl-5-phenyl- and 3-acylvinyl-2-acylmethyl-5-phenyl-1,3,4-thiadiazol-4-ines were obtained by the reaction of terminal α-acetylenic ketones with thiobenzhydrazide. Substituted acetylenic ketones react with thiobenzhydrazide in alcohol to give N,S-bis(acylvinyl)thiobenzhydrazides.

publication date

  • January 1, 1989