Rational design of platinum (IV) compounds to overcome glutathione-S-transferase mediated drug resistance Academic Article uri icon

abstract

  • A rationally designed Pt (IV) anticancer compound is described, employing the novel concept of tethering an inhibitor of glutathione-S-transferase, an enzyme associated with Pt- based drug-resistance, to cisplatin. Its enzyme inhibition activity, investigated using spectrophotometric and mass spectrometry-based techniques, and cytotoxic profile in resistant cancer cells are described.

publication date

  • January 1, 2005