Combination of antidepressant drugs: the case of inositol. Academic Article uri icon


  • Inositol is a second messenger precursor that is effective in depression and obsessive- compulsive disorder via a mechanism different from serotonin reuptake inhibitors. However, controlled trials of inositol combined with serotonin reuptake inhibitors in depression or in reuptake inhibitor resistant depressed patients, or in partially responsive obsessive- compulsive patients, did not reveal added benefit. This is comparable to results with combinations of other antidepressant treatments, such as tricyclics plus monoamine oxidase inhibitors. Copyright© 2001 John Wiley & Sons, Ltd.

publication date

  • January 1, 2001