Pharmacokinetics of glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase and their blood glutamate-lowering activity in naïve rats: 9AP5-2 Academic Article uri icon

abstract

  • Materials and Methods: Forty six male rats were randomly assigned into one of 5 treatment groups: saline (control), human GOT at dose 0.03 and 0.06 mg/kg and porcine GPT at dose 0.6 and 1.2 mg/kg. Blood samples were collected at baseline, 5min, and 2, 4, 8, 12, and 24 hours after the drug injection. Blood was analyzed for GOT, GPT and glutamate concentrations. Results and Discussion: The pharmacokinetics of both GOT and GPT followed a one-compartment model, and both enzymes exhibited substantial glutamate- lowering effects following intravenous administration. Analysis of the pharmacokinetic data indicated that both enzymes were distributed predominantly in the plasma (central circulation) and did not permeate to the peripheral organs and tissues. A several-hour delay was present between the time course of the enzyme concentrations and the glutamate …

publication date

  • June 1, 2012