649: The risk for childhood malignancies in offspring of obese mothers: A population-based cohort study Academic Article uri icon

abstract

  • Objective Fetal origins of adult disease are of major interest. Potential long-term effects of the intrauterine environment on offspring's health have long been studied. We aimed to evaluate the effect of maternal obesity on the long-term risk for childhood malignancies in the offspring. Study Design A population based cohort analysis was performed comparing the risk for long-term childhood malignancies (up to the age of 18 years) in children born to mothers with and without pre-gestational obesity (defined as maternal pre-pregnancy body mass index of 30 kg/m2 or more). Childhood malignancies were pre-defined based on ICD- 9 codes, as recorded in the hospital medical files. Deliveries occurred between the years 1991-2014 in a tertiary medical center. Newborns with congenital malformations and children with benign tumors were excluded from the long term analyses. A Kaplan-Meier …

publication date

  • January 1, 2018