- PROSPECTIVE STUDY ELIEZER BURSTEIN, AMALIA LEVY, ARNON WIZNITZER, DRORA FRAZER, MOSHE MAZOR, EYAL SHEINER, Soroka University Medical Center, Beer-Sheba, Israel, Ben-Gurion University of the Negev, Epidemiology Department, Beer-Sheva, Israel OBJECTIVE: To investigate the outcome of pregnancy in patients with anemia and to determine its association with preterm delivery. STUDY DESIGN: A prospective observational study comparing consecutive pregnancies of women with and without anemia was performed. Maternal anemia was defined as hemoglobin concentration lower than 10 g/dl during pregnancy. Patients with hemoglobinopathies such as thalassemia were excluded from the analysis. A multiple logistic regression model was performed to control for confounders. RESULTS: During the study period there were 487 deliveries. Complete data was abstracted for 460 women, of which 30% (n 138) had maternal anemia. The following conditions were significantly associated with maternal anemia: preterm delivery ( 37 weeks gestation), Apgar scores at 1 minute below 7, cesarean delivery (CD), previous CD, multiple pregnancy, blood transfusions and post-partum hemorrhage (Table). No significant differences were noted between the groups in low Apgar scores at 5 minutes. Using a multiple logistic regression model, maternal anemia was an independent risk factor for preterm delivery (OR 1.9; 95% CI 1.1-3.2; P 0.018). CONCLUSION: Maternal anemia is an independent risk factor for preterm delivery.