Global leukocyte DNA methylation in schizophrenia patients Conference Paper uri icon


  • Objective: Meta-analysis recently suggested that a 5 mM increase in homocysteine is associated with a 70% higher risk for schizophrenia. Elevated homocysteine is reported to alter macromolecule methylation. We studied whether elevated plasma homocysteine levels in schizophrenia are associated with altered global DNA methylation. Methods: DNA was extracted from peripheral blood leukocytes of 28 schizophrenia patients vs. 26 matched healthy controls. Percent of global genome DNA methylation was measured using the cytosine-extension method. Results: Homocysteine levels were about 1.5 fold higher (15.8±10.5 mM vs. 10.6±2.7, p= 0.016) in schizophrenia patients (n= 28) vs. gender-and agematched control subjects (n= 26). No difference in global DNA methylation between schizophrenia patients and control subjects was found (74.0±14.8% vs. 69.4±22.0, p …

publication date

  • July 1, 2008