CYTOKINE ANALYSIS OF MIDDLE EAR EFFUSIONS DURING ACUTE OTITIS MEDIA: SIGNIFICANT REDUCTION IN TUMOR NECROSIS FACTOR ALPHA CONCENTRATIONS CORRELATES WITH BACTERIAL ERADICATION Academic Article uri icon

abstract

  • Acute otitis media (AOM) is a common disease in children. The middle ear is capable of generating an immune response similar to that seen in other parts of the respiratory tract. The inflammatory reaction in this site is complex and multifactorial, involving infectious agents, leukocytes, macrophages and multiple cytokines. 1 Juhn et al. 2 confirmed the presence of significant concentrations of interleukin (IL)-1 and tumor necrosis factor alpha (TNF-alpha) in middle ear effusion (MEF) during AOM. However, the role of cytokines in the pathogenesis, natural history and mechanism of recovery from AOM is unknown. This, in part, is caused by the absence of MEF samples drawn at several times after onset of disease.We utilized MEF samples obtained immediately before antibiotic administration and during the course of treatment, for detection of the proinflammatory cytokine, TNF-alpha …

publication date

  • January 1, 1999