P. 4. d. 009 From over-awareness to obsessive behaviour-error monitoring system dysfunction in patients with obsessive-compulsive disorder Academic Article uri icon


  • Methods: We included 16 out of 32 patients who were treated with DBS between April 2005 and January 2011 at the Academic Medical Center, Amsterdam. After treatment for at least one year, patients entered a 1-week phase in which DBS was switched off. We evaluated psychiatric symptoms and QoL at three time points: before DBS surgery (pre-DBS), following at least one year of DBS treatment (DBS-on) and following 1 week of DBS off (DBS-off). Psychiatric symptoms were assessed with the Yale-Brown obsessive–compulsive disorder scale (Y-BOCS), the Hamilton anxiety rating scale (HAM-A) and the Hamilton depression rating scale (HAM-D). QoL was assessed using the World Health Organization QOL scale (WHOQOL-Bref). Results: Switching from DBS-on to DBS-off, Y-BOCS scores increased significantly with 50%, from 19.94 (SD= 6.92) to 29.90 (SD= 5.74) points [t (15)=− 5.150, p …

publication date

  • January 1, 2014