Real-time genomic investigation underlying the public health response to a Shiga toxin-producing Escherichia coli O26: H11 outbreak in a nursery Academic Article uri icon

abstract

  • Summary Shiga toxin-producing Escherichia coli (STEC) is a significant cause of gastrointestinal infection and the haemolytic-uremic syndrome (HUS). STEC outbreaks are commonly associated with food but animal contact is increasingly being implicated in its transmission. We report an outbreak of STEC affecting young infants at a nursery in a rural community (three HUS cases, one definite case, one probable case, three possible cases and five carriers, based on the combination of clinical, epidemiological and laboratory data) identified using culture-based and molecular techniques. The investigation identified repeated animal contact (animal farming and petting) as a likely source of STEC introduction followed by horizontal transmission. Whole genome sequencing (WGS) was used for real- time investigation of the incident and revealed a unique strain of STEC O26: H11 carrying …

publication date

  • October 1, 2017