Effects of deep transcranial magnetic stimulation of the medial PFC and ACC on relapse to alcohol use and related brain activity Academic Article uri icon


  • Alcohol use disorder (AUD) is a highly prevalent disorder in western countries, with high relapse rate and limited treatment options. Current behavioral and neuropathology evidence point to poor response inhibition capacity and multiple brain network deficits. One of the highlighted hubs in that regard is the anterior cingulate cortex (ACC), which is hypoactive in AUD and plays a central role in inhibitory control, drug craving, and relapse. Here, we attempt to reduce craving levels and relapse rates in short-term abstinent AUD subjects using deep transcranial magnetic stimulation (dTMS) over the medial prefrontal cortex (mPFC) and ACC; while examining neuronal and structural correlation to clinical response. Short-term abstinent AUD patients are treated with either high-frequency (10Hz) or sham dTMS for three weeks in a double-blind manner, with 12 weeks' follow-up. Clinical …

publication date

  • January 1, 2017