Selective Aerobic Oxidation of Methylarenes to Benzaldehydes Catalyzed by N-Hydroxyphthalimide and Cobalt (II) Acetate in Hexafluoropropan-2-ol Academic Article uri icon


  • Abstract Efficient and highly selective catalytic conditions for the aerobic autoxidation of methylarenes to benzaldehydes, based on N-hydroxyphthalimide (NHPI) and cobalt (II) acetate in 1, 1, 1, 3, 3, 3-hexafluoropropan-2-ol (HFIP), were developed. The sustainable conditions enable a multigram scale preparation of benzaldehyde derivatives in high efficiency and with excellent chemoselectivity (up to 99% conversion and 98% selectivity).

publication date

  • January 1, 2017