The neuroprotective effects of oxaloacetate and puruvate in a rat model of subarachnoid hemorrhage is mediated by its blood glutamate scavenging activity: ESAPC... Academic Article uri icon

abstract

  • Materials and Methods: SAH was induced in 60 rats by autologous arterial blood injection into the cisterna magnum. 20 additional rats served as the sham group, with a 0.3 ml saline injection into the cisterna magnum. 60 minutes later, rats were treated with isotonic saline, 250 mg/kg oxaloacetate, or 125 mg/kg pyruvate by intravenous infusion for 30 minutes at a rate of 0.1 ml/100g/min. Prior to the induction of SAH (baseline) and 90 minutes after SAH, blood samples were collected. Rats' neurological status was measured 24 hours following SAH. Glutamate concentrations in the CSF of half of the rats were also measured 24 hours following SAH. The blood brain barrier (BBB) permeability in the parieto‐occipital and frontal lobes was assessed in the remaining half via histological analysis 48 hours following SAH. Results and Discussion: Blood glutamate levels were decreased in rats treated with …

publication date

  • June 1, 2013