Transdermal monitoring of glucose and other analytes using ultrasound Academic Article uri icon

abstract

  • Fig. 1 Ultrasound-enhanced skin permeability. a, Sonophoretic permeability of analytes across human skin in vitro. The final concentrations of the analytes in the collection chamber at the end of the 10-minute extraction period were 0.11 mM for glucose (1.98 mg/dl), 4250 dpm/ml for theophylline, 0.11 mM for urea, and 0.22 mg/dl for calcium. Skin permeability, P, and chamber analyte concentration, C, are related by the equation: C= PCs At/V, where Cs is the serum analyte concentration, A is the chamber area (1.7 cm2), t is the time of extraction, and V is the receiver fluid volume (2 ml). b, Sonophoretic permeability of analytes across rat skin in vivo. The final concentrations of the analytes in the collection chamber at the end of the 15-minute extraction period were 0.073 mM (1.3 mg/dl) for glucose, 0.017 mg/dl for creatinine, 0.061 mg/dl for urea, and 0.059 mg/dl for calcium. ab

publication date

  • January 1, 2000