Epidemiology & outcome in CKD 5D (1) ALTITUDE AND CANCER INCIDENCE IN US DIALYSIS PATIENTSRISK FACTORS OF HEPATIC CANCER AMONG MAINT... Academic Article uri icon

abstract

  • Abstract INTRODUCTION AND AIMS: Higher residential altitude has been associated with greater erythropoietin response and longer survival in ESRD patients. It has been hypothesized that persistent activation of hypoxia-inducible factors (HIF) at higher altitude may explain these associations. Animal models have shown that inactivation of prolyl- hydroxylases-regulators of HIF-suppresses mammary gland proliferation in vitro, with similar findings in lung, brain, and hematopoietic cancer lines. Thus, HIF activation may also …

authors

publication date

  • June 1, 2011