597: Early term deliveries and long-term endocrine and metabolic morbidity of the offspring Academic Article uri icon


  • OBJECTIVE: Adverse Childhood Experiences of pregnant women are associated with adverse pregnancy outcomes, long-term mental and physical health problems that extend into adulthood, and hypothalamic-pituitary-adrenocortical axis (HPA) dysregulation. The objective of this study was to determine whether recalled childhood trauma predicts perinatal stress and mood and both maternal and infant HPA function. STUDY DESIGN: Women were enrolled at< 16 weeks gestation and followed prospectively. The Adverse Childhood Experiences (ACE) scale was used to quantify childhood trauma and compared with: Perceived Stress Scale (PSS), Center for Epidemiologic Studies Depression Scale (CESD), and State-Trait Anxiety Inventory (STAI) scores completed at 16, 22, 28, 34 and 40 weeks gestation. Corticosteroid concentrations (cortisol, cortisone) were measured in …

publication date

  • January 1, 2017