Neutrophil functions in morbidly obese subjects: Neutrophil function in obesity Academic Article uri icon

abstract

  • The present study was set to determine different peripheral blood neutrophil functions in 18 morbidly obese subjects with BMI ranging between 35-69 kg/m(2) in parallel to age and gender matched lean controls. Peripheral blood neutrophils functions of obese subjects and matched lean controls were determined. Neutrophils of obese subjects showed significant elevation of the release of basal superoxides (p<0.0001), fMLP-stimulated superoxides (p<0.0001) and OZ-stimulated superoxides (p<0.045) compared with lean controls. Interestingly, there were no differences in PMA-stimulated superoxide production by neutrophils of the obese subjects and controls. There was also a significant elevation of chemotactic (p<0.0003) and random (p<0.0001) migration of neutrophils from obese subjects compared with lean controls. Phagocytosis, CD11b surface expression and adherence of neutrophils from obese subjects were not significantly different from those of the lean controls. The elevated superoxide production and chemotactic activity together with the normal phagocytosis and adherence suggest that neutrophils from obese subjects are primed and have the capability to combat infections. However, neutrophils in priming state may participate in the pathogenesis obesity related diseases. This article is protected by copyright. All rights reserved. © 2015 British Society for Immunology.

publication date

  • March 1, 2015