HIGH OSTEOPONTIN (OPN) N-TERMINAL/C-TERMINAL RATIO IS ASSOCIATED WITH CAROTID PLAQUE INFLAMMATION: 2A. 05 Academic Article uri icon

abstract

  • Background: Hypertensive patients demonstrate carotid atherosclerotic plaque with enhanced inflammation. The multifunctional protein osteopontin (OPN) is a mediator related to atherosclerosis, hypertension and inflammation. After translation OPN is cleaved by thrombin to form an N-terminal fragment and C-terminal fragment. The N-terminal fragment is known to have an inflammatory property that exceeds those of the full length OPN. However the properties of C-terminal terminal fragment are not well characterized. Aims: The aim of this study is to evaluate whether the ratio of N-terminal/Cterminal OPN fragments correlates with plaque inflammation in hypertensive carotid atherosclerosis. Methods: Carotid plaques were collected from 41 consecutive patients who underwent carotid endarterectomy in our institute from February 2009 to February 2010. After removal, the …

publication date

  • January 1, 2011