- Schreiber, Gabriel, and Sofia Avissar — Lithium Administered by Eye Drops: A Beller Treatment lor Bipolar Affective Disorder? Prog. Neuro-Psychopharmacol. & Biol. Psychial. 1991, 15 :315–321. 1. 1. Bipolar affective patients are suporsensitive to light. 2. 2. Lithium treatment decreases retinal sensitivity to light. 3. 3. Recent findings concerning lithium perlurbation of the function of various members of the G proteins family including transducin (g 1 ), as well as findings of lithium sensitive hyperactive G proteins in mononuclear leukocytes of patients with mania led to the hypothesis that lithium sensitive hyperfunctional g 1 is responsible for the supersensitivity to light in affective patients. 4. 4. Thus, a change in the usual route of lithium administration into eye drops delivery is hypothesized to be more efficient clinically, with the advantages of shortening the lime delay necessary to achieve therapeutic effects, and having less systemic side effects and reduced toxicity.