Sa1486 - Modeling Histologic and Biochemical Improvements of Disease Severity in Chronic Hepatitis B Patients Treated with Long Term Nucleoside Analogues for Up to 18 Years and the Utility of Non-Invasive Biomarkers Academic Article uri icon


  • stemness and these cells are susceptible to transformation. Following DXR-induced injury, Defa4Cre-expressing cells can undergo stem cell reversion and contribute to intestinal regeneration in vivo and enteroid cultures. By contrast, Defa4Cre-expressing cells do not undergo reversion during chronic ileitis indicating their participation in regeneration is dependent on the type of injury. 430 EPITHELIAL-SECRETED WNT LIGANDS ARE ESSENTIAL DRIVERS OF INTESTINAL STEM CELL RESPONSE TO VIRUS-INDUCED VILLUS DAMAGE Winnie Y. Zou, Sarah E. Blutt, Xi-Lei Zeng, Min-Shan Chen, Yuan-Hung Lo, David Castillo-Azofeifa, Ophir D. Kein, Noah F Shroyer, Mark Donowitz, Mary Estes. Introduction. Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage, such as from radiation and chemotherapy, is …

publication date

  • January 1, 2018