Prognosis of heart failure patients undergoing implantation of biventricular pacemaker with and without a defibrillator Academic Article uri icon


  • Purpose: Right ventricular (RV) pacing can impair left ventricular (LV) mechanics. On the other hand, biventricular pacing (BIV) can improve LV efficiency in the setting of ventricular conduction abnormalities. At present, pacing models utilize large animals, which are expensive and can not be manipulated genetically. Here, we studied whether the rodent heart can mimic pacing-related findings in human. Methods: Rats were implanted with two miniature-bipolar-hook electrodes as follows: Group A (n= 6) right atrium (RA) and RV apex (RVa). Group B (n= 7) RVa and posterobasal aspect of the LV (LVpb). Electrodes were attached to a connector in the back. Following recovery, two-dimensional transthoracic echocardiography was performed at baseline (no pacing) and during pacing through the electrodes at a rate slightly faster than the spontaneous heart rate. Segmental 2D …

publication date

  • January 1, 2011