Colonic drug delivery: enhanced release of indomethacin from cross-linked chondroitin matrix in rat cecal content Academic Article uri icon

abstract

  • Colonic drug delivery has gained in interest lately. In addition to sulfasalazine and olsalazine, colon-specific pro-drugs were reported (1-3). In this report we suggest the use of a bioerodible matrix, with the ability to carry a variety of drug molecules into the colon. Chondroitin sulfate (ChS)(Fig. 1) is a soluble mucopolysaccharide consisting of D- glucuronic acid linked to N-acetyl-1)-galactosamide (4, 5). In the human colon, the natural sources of ChS are sloughed epithelial cells and dietary meat. Chondroitin sulfate is utilized as a substrate by the bacteroids of the large intestine, mainly by B. thetai0ta0micron and B. ovatus (6, 7). We suggest, therefore, that ChS could be used as a colonic drug carrier. Such use would depend on its persistence as a solid dosage form in the physiological environment of the stomach and small intestine. Since natural ChS is readily water …

publication date

  • January 1, 1992