Lii-Nao countertransport and Li leak in erythrocytes are differentially affected by membrane enrichment with cholesteryl hemisuccinate Academic Article uri icon


  • Enrichment of erythrocytes with cholesteryl hemisuccinate caused a marked reduction in Li leak but did not change kinetic and thermodynamic properties of Li i -Na o countertransport of either normotensive persons or patients with essential hypertension. As cholesteryl hemisuccinate was shown to affect the membrane similarly to cholesterol, it is likely that the unique thermodynamic properties of erythrocyte Li i -Na o countertransport in essential hypertension are not caused by changes in cholesterol.

publication date

  • January 1, 1986