The effect of inositol on lithium-induced polyuria-polydipsia in rats and humans Academic Article uri icon


  • Abstract It has been proposed that lithium acts by inhibiting inositol monophosphatase, thereby lowering tissue inositol levels. We therefore studied inositol effects on a prominent lithium side-effect, polyuria—polydipsia, in rats and in humans. Rats were treated with daily injections ip LiCl for 14 days and were given 2.5 per cent inositol, 2.5 per cent mannitol or no additive in their drinking water. Fourteen patients complaining of lithium side-effects were recruited for the study after approval by the Helsinki Committee. Patients were treated …

publication date

  • November 1, 1992