Reduced KIR2DL1 recognition of MHC class I molecules presenting phosphorylated peptides Academic Article uri icon


  • Abstract As initially described by K. Karre and colleagues in the missing self hypothesis, cells expressing self-MHC class I proteins are protected from NK cells attack. In contrast, reduction in the expression of MHC class I molecules due to viral infection or tumor transformation result in the killing of these “abnormal” cells by NK cells via NK-activating receptors. Thus, NK killing of target cells is determined by both negative signals coming from MHC class I proteins and by positive signals derived from the activating ligands. The …

publication date

  • June 1, 2006