Loss of Expression of Transplantation Antigens Encoded by the H-2K Locus on Lewis Lung Carcinoma Cells and Its Relevance to the Tumor's Metastatic Properties 2 Academic Article uri icon

abstract

  • The Lewis lung carcinoma 3LL, a C57BL/6 (H-2 b)-originated spontaneous tumor that progresses at the site of transplantation in all mouse strains, produced lung metastases only in mice that shared the H-2D region and the non-H-2 genetic background with the tumor's strain of origin. In vitro cytotoxicity assays revealed that 3LL tumor cells were sensitive to lysis exerted by anti-H-2Db immune effector cells but were relatively resistant to lysis by anti- H-2Kb effector cells. In addition, the 3LL tumor cells could inhibit the anti-H-2Dd response against EL 4 (H-2 b) target cells but had almost no inhibitory effect on the anti-H-2Kb response against the same targets. Immunization of C3HeB (H-2 k) and B10. D2 (H-2 d) mice with 3LL tumor cells resulted in antisera that could preferentially react with H-2Db- positive cells but reacted very weakly with H-2Kb-positive cells. The results indicate that …

publication date

  • July 1, 1983