Rigid, Self-Assembled Hydrogel Composed of a Modified Aromatic Dipeptide Academic Article uri icon


  • Biological building blocks construct complex architectures and machinery through the process of molecular self-assembly. This process offers a new direction for the design and fabrication of novel materials that can be used in various applications such as microelectronics, drug delivery, and tissue engineering.[1–7] Designed and well-ordered structures are formed by in vitro self-assembly of nucleic acid, phospholipid, and polypeptide building blocks.[8–11] Furthermore, the structural and chemical diversity of natural and nonstandard residues that could be integrated into proteins and polypeptides confers upon them some advantages over other building blocks for constructing complex architectures.[2, 3, 12–14] One example of the use of simple proteins as building blocks is the technological application of the proteinaceous supermolecular structures of amyloid fibrils for the …

publication date

  • January 1, 2006